• Anlotinib Hydrochloride: Angiogenesis Assay Guide

  2026-08-22

  Anlotinib hydrochloride enables a layered cancer research workflow that connects receptor phosphorylation, ERK signaling, endothelial cell migration inhibition, and capillary tube formation. This guide translates its VEGFR2, PDGFRβ, and FGFR1 activity into practical assay design, comparative testing, and troubleshooting strategies.

• Anisomycin JNK Agonist Workflow for Apoptosis

  2026-08-22

  Anisomycin offers a practical way to trigger JNK signaling for apoptosis, stress-response, and cancer-cell assays. This workflow pairs dose-controlled pathway activation with mechanistic controls inspired by new findings on neuroligin 1 proteolysis and social memory maintenance.

• Cholesterol: From Membrane Sterol to Assay Variable

  2026-08-21

  Cholesterol is more than a structural lipid: it is a controllable variable linking membrane biophysics, lipid metabolism research, and mRNA nanoparticle performance. This article develops an assay-centered framework grounded in intravesical p21 mRNA–LNP research and practical handling of SKU B1702.

• Mitomycin C Workflows for Apoptosis Research

  2026-08-20

  Build more informative cancer assays with Mitomycin C by pairing DNA replication inhibition with viability, caspase, and death-receptor readouts. This workflow also shows how to use the compound as a host-cell stress comparator when interpreting target-specific CRISPR antiviral experiments.

• Cy3 NHS ester (non-sulfonated): Practical Guide

  2026-08-20

  Cy3 NHS ester (non-sulfonated) provides an orange fluorescent NHS ester for covalent labeling of accessible primary amines on proteins, peptides, and amino-modified oligonucleotides. It is appropriate for workflows that can tolerate DMSO or DMF, but not for water-only labeling or biomolecules that are highly sensitive to organic co-solvents.

• A-769662: Designing Rigorous AMPK Assays

  2026-08-19

  A-769662 is a reversible AMPK activator for dissecting energy metabolism, lipid synthesis, autophagy, and proteasome biology. This guide translates current AMPK findings into better assay controls, interpretation, and type 2 diabetes research workflows.

• InstaBlue Protein Stain Solution: 5-Minute Gel Staining

  2026-08-19

  InstaBlue Protein Stain Solution provides rapid Coomassie Brilliant Blue visualization of protein bands in polyacrylamide gels without fixation, washing, or destaining. It is suitable for routine protein electrophoresis analysis and excision workflows, but stained-band intensity should not be treated as a standalone protein quantification assay without sample-specific calibration.

• Dihydrotestosterone (DHT) Assay Workflows

  2026-08-18

  Learn how Dihydrotestosterone (DHT), SKU B8214, can improve experimental planning for androgen receptor, signaling, and viability assays. This scenario-based guide covers formulation, concentration selection, controls, interpretation, and evidence-based product evaluation.

• Berberine, Tuft Cells, and Estrogen-Deficient Bone Loss

  2026-08-18

  A 2026 study identifies an intestinal butyrate–GPR41–tuft cell pathway through which berberine alleviates estrogen deficiency-associated bone loss in rodents. By combining ovariectomy models, microbiome profiling, immune analysis, knockout mice, and intestinal organoids, the work provides mechanistic evidence that gut barrier repair and Th17/Treg rebalancing can connect intestinal changes with skeletal protection.

• Phosphorylation Integrity in Ischemic Neuron Research

  2026-08-17

  OGD models of neuronal injury increasingly connect ferroptosis with xCT/GPX4-dependent redox failure, but the translational value of those findings depends on preserving phosphorylation during sample preparation. This thought-leadership guide shows how Phosphatase Inhibitor Cocktail 3 can strengthen mechanistic interpretation, assay comparability, and downstream decision-making without overstating what a preanalytical control can prove.

• Nanoparticle Uptake by Human Corneal Cells

  2026-08-17

  Azadi and David examined how nanoparticle size and surface chemistry influence uptake by human corneal epithelial cells, using modified PLGA nanoparticles and an in vitro mucosal model. Their results identify energy-dependent endocytosis, particularly macropinocytosis and caveolae-associated pathways, as a design-relevant basis for improving topical ocular delivery.

• DGLA–ACSL4 Ferroptosis in AML Cells

  2026-08-16

  This study identifies dihomo-γ-linolenic acid (DGLA) as a ferroptosis-promoting lipid in acute myeloid leukemia and connects its activity to ACSL4-dependent lipid metabolic reprogramming. The findings suggest that exploiting ferroptosis may provide a route to target AML cells that evade apoptosis, while also defining experimental controls needed to distinguish ferroptosis from other regulated death pathways.

• A-1155463: A Mechanism-First Path to BCL-XL Translation

  2026-08-15

  A translational framework for using the selective BCL-XL inhibitor A-1155463 to connect apoptotic dependency, resistance biology, and preclinical decision-making across tumor models.

• Baicalein: Designing Better Mechanistic Assays

  2026-08-14

  Baicalein research is strongest when target engagement, cellular phenotype, and treatment selectivity are tested separately. This article uses recent neurotoxicity findings to develop a rigorous assay framework for 12-LOX, apoptosis, inflammation, and cancer biology studies.

• Nystatin (Fungicidin) in Antifungal Assays

  2026-08-14

  Nystatin (Fungicidin) combines direct ergosterol targeting with a useful membrane-pathway control role in cell-entry experiments. This guide connects Candida susceptibility, adhesion assays, liposomal Nystatin for Aspergillus infection, and the S2-cell Spiroplasma model while emphasizing formulation and interpretation safeguards.

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